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Vaccines Indications

TETGLOB® (Tetanus Immunoglobulin B.P.) is indicated for prophylaxis against tetanus following injury in patients whose immunisation is complete or uncertain.
TETGLOB® (Tetanus Immunoglobulin B.P.) should be administered with appropriate wound management. Simultaneous active immunisation must be started using a different injection site and syringe.
TETGLOB® (Tetanus Immunoglobulin B.P.) is also used therapeutically in the treatment of Tetanus, the recommended dose being 4 to 300 units/kg body weight given intramuscularly into different sites. (See DOSAGE & ADMINISTRATION)
TETGLOB® (Tetanus Immunoglobulin B.P.) obtained from human plasma offers the following important advantages compared with the heterologous serum:

Advantage of TETGLOB®(Tetanus Immunoglobulin B.P.) over A.T.S. of animal origin.

Advantage of TETGLOB®(Tetanus Immunoglobulin B.P.) over A.T.S. of animal origin.

SUBJECT
TETGLOB® (Tetanus Immunoglobulin B.P.)
A.T.S
Species
Homologous (Human Donor Plasma)
Heterologous (Animal Origin)
Anaphylactic Reaction None Possible
Protection Period  Small  Large
Protection Dose Prophylaxis: 250 IU
Therapy: 500 – 6,000 IU
Prophylaxis: 1500 IU Therapy: 10,000 – 25,000 IU
Repeated Dose 23 days  8 days
Other Advantages Possible fetal protection as it crosses the placenta No possible fetal protection

Summary of Recommended Dosage Schedule:

INDICATIONS
DOSE
Prophylaxis :
In High risk injuries to non-immune and immune patients(Above 7 Years) 250 IU. Deep IM 500 IU. Deep IM (if 24 hours have not passed since injury or with a risk of heavy contamination)
In High risk injuries to non-immune and immune patients(Below 7 Years) 4 Units/kg or 250 IU Deep IM
Therapeutic : Clinical tetanus Prophylaxis: 250 IU.
Therapy: 500 – 6,000 IU.
Newborn(Tetanus Neonatorum) 250 IU to 500 IU IM and/or 250 IU intrathecal.
Children(Above 7 Years) & Adults 500 to 3,000 IU IM and/or 500 IU intrathecal.

PRESENTATION:

Vials containing Human Tetanus Immunoglobulin equivalent to Tetanus antitoxin 250 / 500 / 1000 IU.

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