Indications
TETGLOB®:(Tetanus Immunoglobulin B.P.) is indicated for prophylaxis against tetanus following injury in-patients whose immunisation is complete or uncertain.
TETGLOB®(Tetanus Immunoglobulin B.P.) should be administered with appropriate wound management. Simultaneous active immunisation must be started using a different injection site and syringe.
TETGLOB®(Tetanus Immunoglobulin B.P.) is also used therapeutically in the treatment of Tetanus, the recommended dose being 4 to 300 units/kg body weight given intramuscularly into different sites. (See DOSAGE & ADMINISTRATION)
TETGLOB®(Tetanus Immunoglobulin B.P.) obtained from human plasma offers the following important advantages compared with the heterologous serum:
Advantage of TETGLOB®(Tetanus Immunoglobulin B.P.) over A.T.S. of animal origin.
SUBJECT |
TETGLOB® (Tetanus Immunoglobulin B.P.) |
A.T.S |
| Species |
Homologous (Human Donor Plasma) |
Heterologous (Animal Origin) |
| Anaphylactic Reaction |
None |
Possible |
| Protection Period |
Small |
Large |
| Protection Dose |
Prophylaxis: 250 I. U.
Therapy: 500 - 6,000 I. U.
|
Prophylaxis: 1500 I. U. Therapy: 10,000 - 25,000 I. U. |
| Repeated Dose |
23 days |
8 days |
| Other Advantages |
Possible fetal protection as it crosses the placenta |
No possible fetal protection |
Summary of Recommended Dosage Schedule:
INDICATIONS |
DOSE |
| Prophylaxis : |
|
| In High risk injuries to non-immune and immune patients (Above 7 Years) |
250 I.U. Deep IM
500 I.U. Deep IM (if 24 hours have not passed since injury or with a risk of heavy contamination) |
| In High risk injuries to non-immune and immune patients (Below 7 Years) |
4 Units/kg or 250 I.U. Deep IM |
| Therapeutic : Clinical tetanus |
Prophylaxis: 250 I. U.
Therapy: 500 - 6,000 I. U.
|
| Newborn (Tetanus Neonatorum) |
250 I.U. to 500 I.U. IM and/or 250 I.U. intra-thecal. |
| Children(Above 7 Years) & Adults |
500 to 3,000 I.U. IM and/or 500 I.U. intra-thecal. |
PRESENTATION:
Vials containing Human Tetanus Immunoglobulin equivalent to Tetanus antitoxin 250 / 500 / 1000 I.U. |
