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Anti Cancer Drugs |
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RELIANCE LIFE SCIENCE - ONCO LIFE DIVISION
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| Material Code |
Material description |
| RGRAST300MCGPFS |
Religrast 300 mcg, 0.5 ml in 1 ml PFS |
| TEMO 20-FPS-22 |
TemoRel-20mg Capsules |
| TEMO100-FPS-23 |
TemoRel-100mg Capsules |
| TEMO250-FPS-24 |
TemoRel-250mg Capsules |
| RELICITABINE-500 |
Relicitabine USP 500 Tablets |
| PEME 500-FPS-0029 |
Relitrexed 500mg |
| RELITREXED-100MG |
Relitrexed 100mg |
| IMATINIB-TAB-100MG |
ImatiRel 100mg |
| IMATINIB-TAB-400MG |
ImatiRel 400mg |
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CISPLATIN INJECTION
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About CISPLATIN INJECTION- 10mg/20ml,50mg/100ml INJECTION
- Cisplatin is a platinum coordination complex. It causes cross linking of DNA; favoured site being N7 of guanine residue. It can also react with –SH groups in proteins and has radiomimetic property. It is bound to plasma proteins, enters, tissues & is slowly excreted unchanged in urine. Cisplatin is very effective in metastatic testicular & ovarian carcinoma. It has found use in some other solid tumours as well.
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| Indication |
- Metastatic testicular and overian carcinoma, advanced bladder, Head & neck cancer.
- Contraindications : Pregnancy, lactation hypersensitivity, renal impairment.
- Drug Interactions : Potentiates neurotoxicity with aminoglycosides. Ideal combination with other cytotoxic drugs.Synergistic with 5-fluorouracil and etoposide.
- Dosage : Admin by slow infusion 10-60 mg or as required.
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| Precautions |
Maintain good hydration.
Shock like state sometimes occurs during i.v. infusion,.
Monitor haematological, neurological status & renal functions.
Hypomagnesaemia. Hypocalcaemia. Hyperuricaemia.
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PACLITAXEL INJECTION
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About Paclitaxel Injection
Paclitaxel is a diterpenoid compound with anti-tumour activity. It binds specifically to the tubulin subunit of microtubule and appears to antagonise the disassembly of this cytoskeletal protein.
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| Indication |
- Metastatic ovarian and breast cancer.
- Contra Indications :Hypersensitivity.
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| Dosage |
- 175 mg per square metre by iv infusion over 3 hrs. repeat every 3 weeks. Pretreat with corticosteroids, antihistaminics and H2 antagonists.
- Special Precautions :Monitor heamatological functions.
- Paediatrics : Not recommended.
- Pregnancy : Not usually prescribec.
- Lactation : Not advised.
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DOCETAXEL INJECTION
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About DOCETAXEL INJECTION 20mg/0.5 ml, 80mg/2ml, & 120mg/3ml
CDocetaxel - It is an anti-neoplastic agent.
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Dosage
- Administered parenterally.
- The dose should be individualized depending on the size of the patient and whether or not other medicines are also being taken. Adults: 60 to 100 mg /1.73 ml intravenously.
Contra Indications
- Hypersensitivity , alcohol abuse or history of, chickenpox, herps zoster, fluid in lungs, infection , liver disease.
- Malignant lymphoma. Gastro-intestinal tract carcinoma. Bronchogenic, bladder, breast & overian carcinoma. Wilm’s tumour. Acute my eloblastic leukaemia. Soft tissue & bone sarcomas.
- Cardiac disease. Hepatic dysfunction.
Special Precautions
- Immunization specifically persons living in the patient’s household should not take oral polio vaccine.
- ECG changes, arrhythmias, hypotension, or be delayed congestive heart failure.
- Paediatrics : Only limited studies are done.
- Pregnancy : Contraindicated.
- Lactation : Generally not recommended.
- Elderly : Use with caution.
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CYCLOPHOSAMIDE INJECTION
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About CYCLOPHOSAMIDE INJECTION 200mg/500mg/1gm
Cyclophosamide is an antineoplastic and immuno modulating agent. It is bio-transformed in liver to active alkylated metabolite. These metabolites interfere with growth of susceptible rapidly multiplying malignant cells by cross-linking of tumour cell-DNA
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Indications
- Hodgekin's disease, lymphocytic lymphogranulomatosis, chronic lymphocytic leukaemia, acute lymphoblastic leukemia, mycosis, adenocarcinoma ovary, carcinoma breast. Also useful in biopsy diagonsed minimal change nephrotic syndrome in children who fail to respond to steroids.
- Contraindications :Pregnancy, lactation
Safety Profile
- Regular haematological profile and urine examination should be done.
Adverse Effects
- Sterility in both sexes may occur, amenorrhoea, haemorrhagic cystitis, fibrosis of bladder, nausea, vomitting, anorexia, alopecia, skin rash, pigmentation, leucopenia, thrombocytopenia, intestinal pulmonary fibrosis, anaphylactic reactions.
Dosage
- In malignant disease : Adult & Children - Initial course 40-50 mg/kg i.v. in divided dose over 2-5 days or 10-15 mg/kg i.v. given every 7-10 days Oral- 1-5 mg/kg/day for both sexes and maintenance phase.
- In combination cytotoxic regimen, it may be necessary to decrease the dose.
- In minimal change disease in children oral; 2.5 to 3mg./kg/day for 60-90 days.
Safety Information
- Paediatrics : Safety is not established in patient with neutropenia or primary/secondary immuno deficiency. Safety is not established in infants under 3 months of age.
- Pregnancy and Lactation : Safety is not established
- Elderly :Safe for elderly with normal renal functions.
- Side–effects :Serious adverse effects are rare. Local IV injection site reaction, site reaction and neutrophilia. Headache, paresthesia, convulsions, oral and vaginal candidiasis.
- Purity : Not less than 99%.
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DOXORUBICIN INJECTION
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About DOXOORUBICIN INJECTION 10mg /50mg
Doxoorubicin is a antitumour antibiotic and finds a useful application in acute leukemia & in many solid tumours. Doxorubicin is capable of cusing breaks in DNA strands and have mutagenic and carcinogenic potential. Maximum action is exerted at S phase, but toxicity is usually exhibited in G2 phase.
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Indications
Malignant lymphoma. Gastro-intestinal tract carcinoma. Bronchogenic, bladder, breast & overian carcinoma. Wilm’s tumour. Acute my eloblastic leukaemia. Soft tissue & bone sarcomas.
Contra Indications : Cardiac disease. Hepatic dysfunction.
Drug Interactions : Cyclosporin, cardiotoxic agents potentiates the cardiotoxicity.
Dosage
- 1.2-2.4 mg/kg body wt or 60-75 mg/sq metre of body surface given as a single dose every 3 week by slow i.v. injection.
Special Precautions
- ECG changes, arrhythmias, hypotension, or be delayed congestive heart failure.
- Paediatrics : Reduced dose necessary.
- Pregnancy : Not usually prescribed.
- Lactation : Not prescribed.
- Elderly : Reduced dose may be necessary.
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